EP0004770A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Pharmaceutical and dietary composition comprising gamma-linolenic acids
Assignee: Efamol Ltd
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Filing: 1979-04-03
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Granted: —
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Expires: 1999-04-03
Abstract
Abstract Compositions and use of y-linolenic acid and related materials with (i) zinc, β-lactam antibiotics or other materials enhancing physiological 1-series PG synthesis and/or (ii) colchicine, Vinca alkaloids or other materials enhancing physiological synthesis of thromboxane A2, for treatment of cancer or inflammatory disorders.
Inventors
- 👤 David Frederick Horrobin
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-05 23:20
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A61K31/33; A61K31/335; A61K31/34; A61K31/395; A61K31/40; A61K31/41; A61K31/425; A61K31/429; A61K31/43; A61K31/435; A61K31/47; A61K31/475; A61K31/557; A61K33/00; A61K33/24; A61K33/30; A61K45/00; A61K45/06; A61P; A61P13/00; A61P13/02; A61P15/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
41 words
A pharmaceutical composition comprising (a) y-linolenic acid or physiologically functional derivative thereof and/or dihomo-y-linolenic acid or physiologically functional derivative thereof and (b) a conjoint amount of a material enhancing physiological synthesis of thromboxane A2, alone or in an acceptable pharmaceutical vehicle.
Claim 2
Dependent Claim
41 words
A pharmaceutical composition comprising (a) y-linolenic acid or physiologically functional derivative thereof and/or dihomo-y-linolenic acid or physiologically functional derivative thereof and (b) a conjoint amount of a material enhancing physiological synthesis of thromboxane A2, alone or in an acceptable pharmaceutical vehicle.
Claim 3
Dependent Claim
53 words
A pharmaceutical composition comprising (a) Y -linolenic acid or physiologically functional derivative thereof and/or dihomo-y-linolenic acid or physiologically functional derivative thereof and (b) a conjoint amount of a material selected from colchicine, other compounds including vinblastine, vincristine, griseofulvin and other Vinca alkaloids, amantadine, melatonin, and interferon, alone or in an acceptable pharmaceutical vehicle.
Claim 4
Dependent Claim
53 words
A pharmaceutical composition comprising (a) Y -linolenic acid or physiologically functional derivative thereof and/or dihomo-y-linolenic acid or physiologically functional derivative thereof and (b) a conjoint amount of a material selected from colchicine, other compounds including vinblastine, vincristine, griseofulvin and other Vinca alkaloids, amantadine, melatonin, and interferon, alone or in an acceptable pharmaceutical vehicle.
Claim 5
Dependent Claim
34 words
The composition of claim 1 or 2, presented for administration in doses comprising 0.05 to 10 g of (a) calculated as linolenic acid, or one half one third or one quarter of said amount.
Claim 6
Dependent Claim
34 words
The composition of claim 1 or 2, presented for administration in doses comprising 0.1 to 1 g of (a) calculated as linolenic acid or one half one third or one quarter of said amount.
Claim 7
Dependent Claim
75 words
The composition of any preceding claim, presented for administration in doses comprising: 0.3 to 15 mg colchicine or 100 to 1000 mg amantadine or 0.5 to 5 g griseofulvin or 35 to 350 mg vinblastine (weekly) or 7 to 70 mg vincristine (weekly) or 1 x 1 0 5 to 1 x 1 0 8 units interferon or 10 mg to 5 g melatonin or one half one third or one quarter of said amount.
Claim 8
Dependent Claim
27 words
A pharmaceutical pack comprising (a) and (b) as set out in any preceding claim, presented separately but for conjoint administration. OIL, COLCHICINE ETC. AND PENICILLIN ETC. CLAIMS
Claim 9
Dependent Claim
26 words
The composition of any one of claims 1 to 5, comprising further (c) a conjoint amount of a material selectively enhancing physiological synthesis of 1-series prostaglandins.
Claim 10
Dependent Claim
27 words
The composition of any one of claims 1 to 5, comprising further (c) a conjoint amount of physiologically assimilable zinc, penicillamine, phenformin, levamisole or a β-lactam antibiotic.
Claim 11
Dependent Claim
30 words
The composition of claim 8, wherein the antibiotic is penicillin G, penicillin N, penicillin V, cephalothin, ampicillin, amoxycillin, cloxacillin, cephalexin, cephaloglycin, or other natural or semi-synthetic penicillin or cephalosporin antibiotic.
Claim 12
Dependent Claim
31 words
The composition of claim 8 or 9, presented for administration in doses comprising 0.5 to 3 g of the antibiotic or one half one third or one quarter of said amount.
Claim 13
Dependent Claim
22 words
The composition of claim 8, presented for administration in doses comprising: or. one half one third or one quarter of said amount.
Claim 14
Dependent Claim
30 words
The composition of claim 8, presented for administration in doses comprising 2.5 to 800 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 15
Dependent Claim
30 words
The composition of claim 8, presented for administration in doses comprising 10 to 200 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 16
Dependent Claim
30 words
The composition of claim 8, presented for adninistration in doses comprising 10 to 80 mg assimilable zinc calculated as the metal, or one half one third or one quarter thereof.
Claim 17
Dependent Claim
33 words
A pharmaceutical or dietary pack comprising (a), (b) and (c), as referred to in any one of claims 7 to 14, presented separately or two together and one separately, but for conjoint administration.
Claim 18
Dependent Claim
5 words
CLAIMS RELATING TO COMPOSITIONS GENERALLY
Claim 19
Dependent Claim
27 words
A composition according to any preceding claim, wherein the physiologically functional derivative of y-linolenic acid or dihomo-γ-linolenic acid is a methyl or ethyl ester or glyceride thereof.
Claim 20
Dependent Claim
37 words
A composition according to any preceding claim, wherein the y-linolenic acid is present in the form of the oil of the seed of Oenothera biennis L., Oenothera lamarckiana, or other Evening Primrose species, or a fraction thereof.
Claim 21
Dependent Claim
33 words
A composition according to any preceding claim, wherein the y-linolenic acid is present in the form of the oil of the seed of Borago officinalis or other Borage species, or a fraction thereof.
Claim 22
Dependent Claim
42 words
A composition according to any preceding claim specifying the presence of zinc, wherein the zinc is present as a salt of a mineral acid or an organic acid (and in particular zinc oleate, y-linolenate or dihomo-y-linolenate), or zinc oxide, or chelated zinc.
Claim 23
Dependent Claim
20 words
A composition according to any preceding claim, comprising further an effective and pharmaceutically acceptable amount of a-tocopherol or other antioxidant.
References Cited (Backward Citations)
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