Patent US6959288B1 successfully refreshed from Google Patents.
CA2012175A1
Expired / Lapsed
CA
⏱️ 0.0 years remaining
Photochemical treatment of blood vessels
Assignee: University of California, San Diego
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Filing: 1990-03-14
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Granted: —
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Expires: 2010-03-14
Abstract
Abstract PHOTOCHEMICAL TREATMENT OF BLOOD VESSELS Abstract of the Disclosure A method for treating blood vessels to destroy the blood vessel without damaging surrounding tissue. The method involves introducing a photoreactive compound into the blood flowing through the blood vessel and allowing the photoreactive compound to accumulate in the blood vessel wall. The photoreactive compound is activated by exposure to radiation prior to accumulation of the reactive compound into surrounding tissues. The activation of the photoreactive compound prior to movement into surrounding tissues provides selective destruction of blood vessels while limiting destruction of surrounding tissues.
Inventors
- 👤 Michael W. Berns
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-11-07 15:53
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/06; A61N5/0613; A61N5/062; A61N5/067
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
200 words
A method for photochemically treating an area of the skin that contains at least one blood vessel wherein said blood vessel includes a blood vessel wall comprising blood vessel tissue cells, said blood vessel wall having an interior surface defining a blood flow zone through which blood flows and an exterior surface which defines the outer perimeter of said blood vessel, wherein the method comprises: introducing a therapeutic amount of a photoreactive compound into the blood flowing through said blood flow zone wherein said photoreactive compound is capable of accumulating in said blood vessel wall from said blood vessel interior surface toward said blood vessel exterior surface and wherein said photoreactive compound destroys blood vessel tissue and other tissue cells upon activation; allowing said photoreactive compound to accumulate in said blood vessel wall for a sufficient time to provide a sufficient amount of photoreactive compound within said blood vessel wall to destroy said blood vessel when said photoreactive compound is activated; and activating said photoreactive compound in said blood vessel wall prior to movement of said photoreactive compound past the outer perimeter of said blood vessel to thereby limit destruction of tissue surrounding said blood vessel by said photoreactive compound.
Claim 2
Independent Claim
200 words
A method for photochemically treating an area of the skin that contains at least one blood vessel wherein said blood vessel includes a blood vessel wall comprising blood vessel tissue cells, said blood vessel wall having an interior surface defining a blood flow zone through which blood flows and an exterior surface which defines the outer perimeter of said blood vessel, wherein the method comprises: introducing a therapeutic amount of a photoreactive compound into the blood flowing through said blood flow zone wherein said photoreactive compound is capable of accumulating in said blood vessel wall from said blood vessel interior surface toward said blood vessel exterior surface and wherein said photoreactive compound destroys blood vessel tissue and other tissue cells upon activation; allowing said photoreactive compound to accumulate in said blood vessel wall for a sufficient time to provide a sufficient amount of photoreactive compound within said blood vessel wall to destroy said blood vessel when said photoreactive compound is activated; and activating said photoreactive compound in said blood vessel wall prior to movement of said photoreactive compound past the outer perimeter of said blood vessel to thereby limit destruction of tissue surrounding said blood vessel by said photoreactive compound.
Claim 3
Dependent Claim
14 words
A method according to claim 1 wherein said photoreactive compound is a hematoporphyrin compound.
Claim 4
Dependent Claim
13 words
A method according to claim 2 wherein said photoreactive compound is hematoporphyrin derivative.
Claim 5
Dependent Claim
13 words
A method according to claim 2 wherein said photoreactive compound is Photofrin II.
Claim 6
Dependent Claim
26 words
A method according to claim 2 wherein said hematoporphyrin compound is activated by irradiation with light having a wavelength of between about 400 to 700 nanometers.
Claim 7
Dependent Claim
19 words
A method according to claim 5 wherein the wavelength of said radiation is between about 700 and 650 nanometers.
Claim 8
Dependent Claim
13 words
A method according to claim 6 wherein said photoreactive compound is Photofrin II.
Claim 9
Dependent Claim
18 words
A method according to claim 1 wherein said blood vessels are located in the skin of a mammal.
Claim 10
Dependent Claim
17 words
A method according to claim 8 wherein said blood vessels are located in a hypervascular dermal lesion.
Claim 11
Dependent Claim
13 words
A method according to claim 9 wherein said photoreactive compound is hematoporphyrin compound.
Claim 12
Dependent Claim
13 words
A method according to claim 10 wherein said photoreactive compound is hematoporphyrin derivative.
Claim 13
Dependent Claim
13 words
A method according to claim 11 wherein said photoreactive compound is Photofrin II.
Claim 14
Dependent Claim
26 words
A method according to claim 9 wherein said photoreactive compound is activated by exposure to radiation having a wavelength of between about 400 to 700 nanometers.
Claim 15
Dependent Claim
19 words
A method according to claim 9 wherein the wavelength of said radiation is between about 600 and 650 nanometers.
Claim 16
Dependent Claim
24 words
A method according to claim 12 wherein said Photofrin II is exposed to radiation having a wavelength of between about 600 and 650 nanometers.
Claim 17
Dependent Claim
16 words
A method according to claim 9 wherein said hypervascular dermal lesion is port-wine-stains or spider veins.
Claim 18
Dependent Claim
12 words
A method according to claim 8 wherein said mammal is a human.
Claim 19
Dependent Claim
12 words
A method according to claim 9 wherein said mammal is a human.
Claim 20
Dependent Claim
26 words
A method according to claim 1 wherein said photoreactive compound is allowed to accumulate in said blood vessel wall for about 2 hours prior to activation.
References Cited (Backward Citations)
No citation records indexed.
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