CA1245154A
Expired / Lapsed
CA
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Method of inactivating reproductive filterable pathogens
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1985-09-12
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Granted: 1988-11-22
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Expires: 2005-09-12
Abstract
Abstract ABSTRACT OF THE DISCLOSURE: There is disclosed a method of inactivating reproductive filterable pathogens in tissue adhesives containing fibri-nogen and Factor XIII, with their biologic activity being largely preserved. In order to provide a tissue adhesive preparation of human or animal origin, which exhibits a high safety with respect to reproductive filterable patho-gens and whose biologic activity is largely preserved, preparations having a minimum content of 100 units of Factor XIII/g of fibrinogen are heated in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Inventors
- 👤 Thomas Seelich
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-11-06 12:26
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/04; A61L2103/00; A61L2103/05; A61L2103/09
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
60 words
A method of inactivating reproductive filterable patho-gens in a tissue adhesive preparation containing fibrin-ogen and Factor XIII, with its biologic activity being largely preserved, which method comprises heating a tissue adhesive preparation having a minimum content of 100 units of Factor XIII/g of fibrinogen in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Claim 2
Independent Claim
60 words
A method of inactivating reproductive filterable patho-gens in a tissue adhesive preparation containing fibrin-ogen and Factor XIII, with its biologic activity being largely preserved, which method comprises heating a tissue adhesive preparation having a minimum content of 100 units of Factor XIII/g of fibrinogen in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Claim 3
Dependent Claim
14 words
A method as set forth in claim 1, wherein said protec-tive gas is nitrogen.
Claim 4
Dependent Claim
36 words
A method as set forth in claim 1, wherein said heating of said tissue adhesive preparation is effected at a temperature of between 50 and 120°C for a period of time of at least 1 min.
Claim 5
Dependent Claim
26 words
A method as set forth in claim 1, wherein said dry state of said tissue adhesive preparation is brought about by after-drying with a water-binding agent.
Claim 6
Dependent Claim
15 words
A method as set forth in claim 4, wherein said water-binding agent is phosphorus pentoxide.
Claim 7
Independent Claim
77 words
A method of inactivating reproductive filterable patho-gens in a tissue adhesive preparation containing fibrin-ogen and Factor XIII, with its biologic activity being largely preserved, which method comprises producing said tissue adhesive preparation having a native content on Factor XIII by fractionation of human cryoprecipitate, adding further Factor XIII to said native content of Factor XIII, and heating said tissue adhesive preparation in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Claim 8
Independent Claim
77 words
A method of inactivating reproductive filterable patho-gens in a tissue adhesive preparation containing fibrin-ogen and Factor XIII, with its biologic activity being largely preserved, which method comprises producing said tissue adhesive preparation having a native content on Factor XIII by fractionation of human cryoprecipitate, adding further Factor XIII to said native content of Factor XIII, and heating said tissue adhesive preparation in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Claim 9
Dependent Claim
19 words
A method as set forth in claim 6, wherein said heating is effected in any stage during said fractionation.
Claim 10
Dependent Claim
30 words
A method as set forth in claim 6, further comprising filling said preparation into final containers, and wherein said heating is effected after filling said preparation into said fi-nal containers.
Claim 11
Dependent Claim
28 words
A method as set forth in claim 8, wherein said heating is effected in any stage of said fractionation and after filling said preparation into said final containers.
Claim 12
Dependent Claim
34 words
A method as set forth in claim 6, or 7, wherein said adding of further Factor XIII is effected until a total content of Factor XIII of about 500 units/g of fibrinogen is reached.
Claim 13
Dependent Claim
34 words
A method as set forth in claim 8, or 9 wherein said adding of further Factor XIII is effected until a total content of Factor XIII of about 500 units/g of fibrinogen is reached.
References Cited (Backward Citations)
No citation records indexed.
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