CA1156529A
Expired / Lapsed
CA
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Fibrous collagenous hemostatic-adhesive webs
Assignee: Avicon Inc
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Filing: 1981-06-03
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Granted: 1983-11-08
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Expires: 2001-06-03
Abstract
Abstract ABSTRACT OF THE DISCLOSURE A fibrous, velvet-like, non-woven web having hemostatic and adhesive properties adapted to seal a wound comprising fibers of collagen or an ionizable, water-insoluble, partial salt of collagen. The web is formed by slurrying the fibers, which have hemostatic and adhesive properties, in an aqueous liquid, introducing a predetermined amount of slurry into a tray and freeze drying the slurry.
Inventors
- 👤 Fred A. Serravallo
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-10-31 13:15
CPC Classifications
D; D21; D21H; D21H13/00; D21H13/10; D21H13/28; D21H13/34; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; D21H5/00; D21H5/12; D21H5/1209; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
106 words
The method of forming a velvet-like, hemostat-adhesive, fibrous, non-woven web dressing for severed biological surfaces from hemostat-adhesive fibers consisting essentially of collagen or an ionizable, water-insoluble, partial salt of collagen containing from about 50 to about 90% of the theoretical stoichiometric amount of ionizable acid, characterized by the steps of preparing a slurry of the fibers in an aqueous liquid, the slurry containing from 0.5 to 3.5% fibers, by weight, introducing a predetermined amount of the slurry into a freeze-drier tray, freeze drying the slurry and recovering a hemostat-adhesive, fibrous, non-woven web which, when placed on a wound and wet with blood, self-adheres to the wound.
Claim 2
Independent Claim
106 words
The method of forming a velvet-like, hemostat-adhesive, fibrous, non-woven web dressing for severed biological surfaces from hemostat-adhesive fibers consisting essentially of collagen or an ionizable, water-insoluble, partial salt of collagen containing from about 50 to about 90% of the theoretical stoichiometric amount of ionizable acid, characterized by the steps of preparing a slurry of the fibers in an aqueous liquid, the slurry containing from 0.5 to 3.5% fibers, by weight, introducing a predetermined amount of the slurry into a freeze-drier tray, freeze drying the slurry and recovering a hemostat-adhesive, fibrous, non-woven web which, when placed on a wound and wet with blood, self-adheres to the wound.
Claim 3
Dependent Claim
15 words
The method as defined in claim 1 characterized in that the aqueous liquid is water.
Claim 4
Dependent Claim
26 words
The method as defined in claim 1 characterized in that the aqueous liquid is water and the slurry contains from 0.5 to 2.5% fibers, by weight.
Claim 5
Dependent Claim
16 words
The method as defined in claim 1 characterized in that the fibers consist essentially of collagen.
Claim 6
Dependent Claim
35 words
The method as defined in claim 1 characterized in that the fibers consist essentially of an ionizable, water-insoluble, partial salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of ionizable acid.
Claim 7
Dependent Claim
24 words
The method as defined in claim 5 characterized in that the fibers consist essentially of an ionizable, water-insoluble, partial hydrogen chloride salt of collagen.
Claim 8
Dependent Claim
20 words
The method as defined in claim 1 characterized in that the aqueous liquid is a mixture of water and ethanol.
Claim 9
Dependent Claim
35 words
The method as defined in claim 1 characterized in that the slurry is frozen at a temperature of -40°C. and the frozen slurry dried at a temperature of 38-40°C. under a pressure of 50 microns.
Claim 10
Dependent Claim
106 words
A hemostat-adhesive dressing for severed biological surfaces and formed by the method of claim 1, characterized by a fibrous, velvet-like, porous non-woven, hemostat-adhesive web consisting essentially of fibers of collagen or an ionizable, water-insoluble partial salt of collagen containing from 50 to 90% of the theoretical stoichiometric amount of ionizable acid, the web having a thickness of from 2 to 10 mm., a basis weight of from 25 to 250 g. per sq. m., a tensile strength of from 20 to 900 gms. per 12.7 mm. width, and being characterized in that, when placed on a wound and wet with blood, it self-adheres to the wound.
Claim 11
Dependent Claim
23 words
A hemostat-adhesive dressing as defined in claim 9 characterized in that the web has a stiffness factor of from 30 to about 85.
Claim 12
Dependent Claim
38 words
A hemostat-adhesive dressing as defined in claim 9 characterized in that the web consists essentially of fibers of collagen and the web has a water holding capacity of 5 to 10 grams of water per gram of web.
Claim 13
Dependent Claim
45 words
A hemostat-adhesive dressing as defined in claim 9 characterized in that the web consists essentially of fibers of an ionizable, water-insoluble partial salt of collagen and the web has a water holding capacity of from 20 to 300 grams of water per gram of web.
Claim 14
Dependent Claim
111 words
A hemostat-adhesive dressing as defined in claim 9 characterized in that the web consists essentially of fibers of collagen or an ionizable, water-insoluble partial salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of ionizable acid, the web having a thickness of from 2.5 to 7 mm., a basis weight of from 80 to 200 gms. per sq. m., a tensile strength of from 30 to 450 gms. per 12.7 mm. width, a stiffness factor of from 35 to 75 and a porosity such that 75% of the pores have diameters not exceeding about 10 to 11 microns and all pores have diameters not exceeding 15 microns.
Claim 15
Dependent Claim
38 words
A hemostat-adhesive dressing as defined in claim 13 characterized in that the web consists essentially of fibers of collagen and the web has a water holding capacity of 5 to 10 grams of water per gram of web.
Claim 16
Dependent Claim
60 words
A hemostat-adhesive dressing as defined in claim 13 characterized in that the web consists essentially of fibers of an ionizable, water-insoluble partial hydrogen chloride salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of hydrogen chloride and the web has a water holding capacity of from 20 to 30 grams of water per gram of web.
References Cited (Backward Citations)
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