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CA1146866A Expired / Lapsed CA ⏱️ 0.0 years remaining

Process for the production of sustained release pharmaceutical composition of solid medical material

Assignee: Astellas Pharma Inc
•
Filing: 1980-06-19
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Granted: 1983-05-24
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Expires: 2000-06-19
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Abstract

Abstract ABSTRACT OF THE DISCLOSURE Sustained release pharmaceutical compositions of solid medical material contains the amorphous solid medical material, polyethylene oxide, and at last one basic substance selected from the group consisting of hydroxy-propylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate metal acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid. Optionally, the composition may further contain another basic substance selected from the group consisting of surface active agent, polyethylene glycol, propylene glycol, glycerin, glycerin fatty acid ester and vegetable oil. According to another aspect of the invention, a sustained release pharmaceutical composition of amorphous nicardipine compounded with polyethylene oxide is provided.

Inventors

  • 👤 Chiharu Sone
  • 👤 Satoru Yoneya
  • 👤 Hiroitsu Kawata
  • 👤 Tadayoshi Ohmura
  • 👤 Masayoshi Aruga
  • 👤 Takashi Sonobe

Bibliographic Details

Application Number —
Jurisdiction CA
Data Source google_patents
Last Synchronized 2026-10-30 17:56
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/141; A61K9/146; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/16; A61K9/1605; A61K9/1611

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 88 words
The process of producing a sustained release pharmaceutical composition of a solid medical material which comprises dissolving a solid medical material and at least one substance selected from a first group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinyl-pyridin-methyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid in water or an organic solvent, distilling off the solvent and adding polyethylene oxide.
Claim 2
Dependent Claim 88 words
The process of producing a sustained release pharmaceutical composition of a solid medical material which comprises dissolving a solid medical material and at least one substance selected from a first group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinyl-pyridin-methyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid in water or an organic solvent, distilling off the solvent and adding polyethylene oxide.
Claim 3
Dependent Claim 65 words
The process of claim 1, further comprising dissolving with said solid medical material and the selected one or more substances from said first group at least one substance selected from a second group consisting of surface active agent, polyethylene glycol, propylene glycol, glycerin, glycerin fatty acid ester and vegetable oil in water or an organic solvent, distilling off the solvent and then adding polyethylene oxide.
Claim 4
Dependent Claim 37 words
The process of claim 1, which comprises dissolving said solid medical material and the selected one or more substance from said first group with polyethylene oxide in water or an organic solvent and distilling off the solvent.
Claim 5
Dependent Claim 40 words
The process of claim 2, which comprises dissolving said solid medical material, the one or more selected substances from each of said first and second group with polyethylene oxide in water or an organic solvent and distilling off the solvent.
Claim 6
Dependent Claim 33 words
A process for producing a substained release pharmaceutical composition of nicardipine or a salt thereof comprising compounding amorphous nicardipine or its salt in fine powder form with a fine powder of polyethylene oxide.
Claim 7
Dependent Claim 33 words
A process for producing a substained release pharmaceutical composition of nicardipine or a salt thereof comprising compounding amorphous nicardipine or its salt in fine powder form with a fine powder of polyethylene oxide.
Claim 8
Dependent Claim 20 words
The process of claim 5, wherein amorphous nicardipine or its salt is that obtained by friction pulverizing to fine powder.
Claim 9
Dependent Claim 20 words
The process of claim 6, wherein the friction pulverizing is performed with a ball mill or a vibrating ball mill.
Claim 10
Dependent Claim 24 words
A sustained release pharmaceutical composition comprising amorphous nicardipine or its salt in fine powder form compounded with a fine powder form of polyethylene oxide.
Claim 11
Dependent Claim 24 words
A sustained release pharmaceutical composition comprising amorphous nicardipine or its salt in fine powder form compounded with a fine powder form of polyethylene oxide.

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