CA1044142A
Expired / Lapsed
CA
⏱️ 0.0 years remaining
Anti-inflammatory dipeptide
Assignee: Individual
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Filing: 1975-07-04
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Granted: 1978-12-12
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Expires: 1995-07-04
Abstract
Abstract Abstract of the Disclosure The pharmaceutical composition has a dipeptide or a pharmaceutically-acceptable salt thereof as an active ingredient. The dipeptide has the general formula: wherein R1 and R2 are the same or different and each is either phenyl or indolyl. The composition may be in a solid form for oral administration in which case the active ingredient is surrounded by an enteric coating. The composition may also be in a liquid form for admini-stration by injection in which case the active ingredient is dissolved in a physiologically compatible sterile liquid. The composition is useful in the treatment of infiammation in mammals and may be administered daily in an amount of about 40mg of the dipetide or salt per kilogram weight of the mammal.
Inventors
- 👤 John N. Mcarthur
- 👤 Peter D. Dawkins
- 👤 Mervyn J. H. Smith
Bibliographic Details
Application Number
—
Jurisdiction
CA
Data Source
google_patents
Last Synchronized
2026-10-26 03:54
CPC Classifications
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Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
113 words
A pharmaceutical composition in a solid form for oral administration or in a liquid form for administration by injection, said composition being useful in the treatment of inflammation and having as active ingredient a dipeptide or a pharmaceutically acceptable salt thereof, said dipeptide having the general formula: wherein R1 and R2 are the same or different and each is either phenyl or indolyl, said active ingredient when said composi-tion is in a solid form being surrounded by an enteric coating and when said composition is in a liquid form being dissolved in a physiologically compatible sterile liquid, the amount of said active ingregient present in said composition being an amount effective against inflammation.
Claim 2
Dependent Claim
113 words
A pharmaceutical composition in a solid form for oral administration or in a liquid form for administration by injection, said composition being useful in the treatment of inflammation and having as active ingredient a dipeptide or a pharmaceutically acceptable salt thereof, said dipeptide having the general formula: wherein R1 and R2 are the same or different and each is either phenyl or indolyl, said active ingredient when said composi-tion is in a solid form being surrounded by an enteric coating and when said composition is in a liquid form being dissolved in a physiologically compatible sterile liquid, the amount of said active ingregient present in said composition being an amount effective against inflammation.
Claim 3
Dependent Claim
106 words
A pharmaceutical composition in a solid form for oral administration or in a liquid form for administration by injection, said composition being useful in the treatment of inflammation and having as active ingredient a dipeptide or a pharmaceutically-acceptable salt thereof, said dipeptide being selected from the group consisting of D-phenylalanyl-D-phenylalanine, D-phenylalanyl-D-tryptophan, D-tryptophanyl-D-phenylalanine, D-tryptophanyl D-tryptophan, and L-tryptophanyl-L-tryptophan, said active ingredient when said composition is in a solid form being surrounded by an enteric coating and when said composition is in a liquid form being dissolved in a physiologically compatible sterile liquid, the amount of said active ingredient present in said composition being an amount effective against inflammation.
Claim 4
Dependent Claim
106 words
A pharmaceutical composition in a solid form for oral administration or in a liquid form for administration by injection, said composition being useful in the treatment of inflammation and having as active ingredient a dipeptide or a pharmaceutically-acceptable salt thereof, said dipeptide being selected from the group consisting of D-phenylalanyl-D-phenylalanine, D-phenylalanyl-D-tryptophan, D-tryptophanyl-D-phenylalanine, D-tryptophanyl D-tryptophan, and L-tryptophanyl-L-tryptophan, said active ingredient when said composition is in a solid form being surrounded by an enteric coating and when said composition is in a liquid form being dissolved in a physiologically compatible sterile liquid, the amount of said active ingredient present in said composition being an amount effective against inflammation.
Claim 5
Dependent Claim
27 words
The composition as claimed in Claims 1 or 2 wherein said composition is in a solid form and said enteric coating is shellac or cellulose acetate phthalate.
Claim 6
Dependent Claim
51 words
The composition as claimed in Claims 1 or 2 wherein said composition is in a liquid form and said sterile liquid is water to which is added a base to cause dissolution of said active ingredient and afterward to which is added an acid to decrease the pH to about 7.2.
Claim 7
Dependent Claim
51 words
The composition as claimed in Claims 1 or 2 wherein said composition is in a liquid form and said sterile liquid is water to which is added sodium hydroxide to cause dissolu-tion of said active ingredient and afterward to which is added hydrochloric acid to decrease the pH to about 7.2.
References Cited (Backward Citations)
No citation records indexed.
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