Slow release oral pharmaceutical compsn. - having excipient contg. di:methyl-polysiloxane, silica, polymeric carbohydrate(s) and algae

Abstract

Abstract Slow-release pharmaceutical compsn. for oral admin. comprises (1) an active ingredient and (2) as pharmaceutically acceptable excipient a mixt.of at least dimethylpolysiloxane (I), silicic acid (II), mannans and/or galactans (III), xanthans (IV) and micronised algae (V). Pref. the excipient contains (by wt.) 15-50, esp. 25, pts. (I); 30-100, esp. 50, pts. (II); 30-100, esp. 50, pts. (III); 50-150, esp. 75, pts. (IV); and 5-75, esp. 50, pts. (V). - Component (I) is esp. dimethylpolysiloxane 500 and (III) is esp. a mixt.of both mannan and galactan. Suitable active ingredients are xanthine derivs., anti-inflammatories, beta-blockers, Ca inhibitors, antiepileptics, benzodiazepines, diuretics, analgesics, hormones and anti-depressants. Formulations are tablets, capsules or granules and the active ingredient:excipient wt. ratio is 1:5-5:1, esp. with 5-500 mg. active ingredient per unit dose.

Inventors

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